Two sample MR report

Telomere_length against aparc-a2009s lh area G-parietal-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0878120	0.0994056	0.3870376
Weighted median	23	-0.0131156	0.0598711	0.8266003
Inverse variance weighted	23	-0.0158161	0.0388451	0.6838928
Simple mode	23	-0.0828471	0.1048216	0.4377528
Weighted mode	23	-0.0498835	0.0892526	0.5818737

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.88546	21	0.5285263
Inverse variance weighted	21.16808	22	0.5103722

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0063628	0.0056182	0.2701788

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006465	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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