Two sample MR report

Telomere_length against aparc-a2009s lh area G-orbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0317072	0.1438392	0.8276613
Weighted median	23	0.0134040	0.0603664	0.8242799
Inverse variance weighted	23	0.0180428	0.0551007	0.7433268
Simple mode	23	0.0016499	0.1019070	0.9872289
Weighted mode	23	-0.0077059	0.0737615	0.9177422

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.96868	21	0.0023601
Inverse variance weighted	44.26429	22	0.0032863

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030546	0.0081295	0.7108722

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013478	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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