Two sample MR report

Telomere_length against aparc-a2009s lh area G-oc-temp-med-Parahip

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0276899	0.1288913	0.8319711
Weighted median	23	-0.0884288	0.0527098	0.0934147
Inverse variance weighted	23	-0.0569443	0.0492807	0.2478821
Simple mode	23	-0.0598503	0.0861184	0.4943455
Weighted mode	23	-0.0677761	0.0574719	0.2508790

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.30597	21	0.0261271
Inverse variance weighted	35.40819	22	0.0351030

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017962	0.0072846	0.8076308

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001138	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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