Two sample MR report

Telomere_length against aparc-a2009s lh area G-oc-temp-med-Lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0606047	0.0994029	0.5486096
Weighted median	23	0.0366728	0.0646604	0.5706055
Inverse variance weighted	23	0.0052694	0.0388446	0.8920957
Simple mode	23	0.0288043	0.1279107	0.8239096
Weighted mode	23	0.0427078	0.1336561	0.7523352

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.55174	21	0.4865940
Inverse variance weighted	20.91748	22	0.5258427

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0033977	0.0056181	0.5518141

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006344	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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