Two sample MR report

Telomere_length against aparc-a2009s lh area G-oc-temp-lat-fusifor

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.1249564 0.1019090 0.2337122
Weighted median 23 0.0978172 0.0610670 0.1091997
Inverse variance weighted 23 0.0154208 0.0401512 0.7009273
Simple mode 23 0.1004692 0.1157781 0.3948854
Weighted mode 23 0.1377751 0.0822443 0.1080536

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 22.07157 21 0.3953957
Inverse variance weighted 23.50463 22 0.3737203

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0067255 0.0057597 0.2560216

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.000717 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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