Two sample MR report

Telomere_length against aparc-a2009s lh area G-occipital-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0090425	0.1219597	0.9415981
Weighted median	23	-0.0045674	0.0582196	0.9374689
Inverse variance weighted	23	-0.0176464	0.0465697	0.7047442
Simple mode	23	-0.0234408	0.1100894	0.8333458
Weighted mode	23	0.0551459	0.0793683	0.4944475

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.61084	21	0.0640756
Inverse variance weighted	31.61968	22	0.0841152

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005283	0.0068929	0.9396347

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009644	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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