Two sample MR report

Telomere_length against aparc-a2009s lh area G-occipital-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0839676	0.0994060	0.4078027
Weighted median	23	0.0347816	0.0550831	0.5277532
Inverse variance weighted	23	0.0708017	0.0388453	0.0683549
Simple mode	23	0.1606611	0.0996533	0.1211727
Weighted mode	23	-0.0080905	0.0730424	0.9128076

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.21455	21	0.8602082
Inverse variance weighted	17.07550	22	0.7591813

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0095028	0.0056182	0.1055424

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006181	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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