Two sample MR report

Telomere_length against aparc-a2009s lh area G-insular-short

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1002041	0.1304443	0.4509352
Weighted median	23	-0.0498612	0.0586450	0.3952019
Inverse variance weighted	23	0.0045093	0.0506959	0.9291233
Simple mode	23	-0.0045164	0.1089796	0.9673169
Weighted mode	23	-0.0467728	0.0686868	0.5030032

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.16170	21	0.0209681
Inverse variance weighted	37.47133	22	0.0209866

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0064293	0.0073724	0.393023

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011358	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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