Two sample MR report

Telomere_length against aparc-a2009s lh area G-front-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0227862	0.1146064	0.8443148
Weighted median	23	0.0285592	0.0612040	0.6407691
Inverse variance weighted	23	-0.0318103	0.0437631	0.4673022
Simple mode	23	-0.0343102	0.1015873	0.7387602
Weighted mode	23	0.0032028	0.0731242	0.9654598

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.91325	21	0.142629
Inverse variance weighted	27.92297	22	0.178248

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005541	0.0064773	0.9326408

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008664	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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