Two sample MR report

Telomere_length against aparc-a2009s lh area G-front-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1279805	0.1065746	0.2431781
Weighted median	23	-0.1317515	0.0580490	0.0232282
Inverse variance weighted	23	-0.0961585	0.0407911	0.0184063
Simple mode	23	-0.1788847	0.1053653	0.1036561
Weighted mode	23	-0.1288181	0.0686158	0.0737891

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.13855	21	0.2863938
Inverse variance weighted	24.25950	22	0.3337753

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019539	0.0060234	0.7488575

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009208	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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