Two sample MR report

Telomere_length against aparc-a2009s lh area G-front-inf-Triangul

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0947288	0.0994046	0.3514500
Weighted median	23	-0.0996764	0.0566555	0.0785194
Inverse variance weighted	23	-0.0566287	0.0388449	0.1448917
Simple mode	23	0.0133213	0.1131810	0.9073742
Weighted mode	23	-0.0913805	0.0776438	0.2518046

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.58370	21	0.5477496
Inverse variance weighted	19.75708	22	0.5982317

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023394	0.0056182	0.6813479

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006631	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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