Two sample MR report

Telomere_length against aparc-a2009s lh area G-front-inf-Orbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0188515	0.0994071	0.8514131
Weighted median	23	0.0858708	0.0603836	0.1550007
Inverse variance weighted	23	0.0603221	0.0388459	0.1204569
Simple mode	23	0.0840006	0.0958558	0.3903229
Weighted mode	23	0.0965184	0.0742072	0.2068344

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.59150	21	0.6113265
Inverse variance weighted	19.34018	22	0.6242391

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048613	0.0056183	0.3966744

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006591	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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