Two sample MR report

Telomere_length against aparc-a2009s lh area G-front-inf-Opercular

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1535391	0.0994050	0.1373844
Weighted median	23	-0.0959055	0.0586572	0.1020455
Inverse variance weighted	23	-0.0510313	0.0388450	0.1889420
Simple mode	23	-0.0351516	0.1104828	0.7533611
Weighted mode	23	-0.1472808	0.0810754	0.0829308

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.92448	21	0.7156740
Inverse variance weighted	18.17954	22	0.6952921

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006294	0.0056182	0.275238

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006032	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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