Two sample MR report

Telomere_length against aparc-a2009s lh area G-cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0131702	0.1293450	0.9198636
Weighted median	23	-0.0081501	0.0594988	0.8910470
Inverse variance weighted	23	0.0299235	0.0494064	0.5447402
Simple mode	23	-0.1401952	0.1188880	0.2509060
Weighted mode	23	-0.0928840	0.0927256	0.3273756

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.55639	21	0.0245092
Inverse variance weighted	35.58992	22	0.0335825

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010287	0.0073103	0.8894378

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010964	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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