Two sample MR report

Telomere_length against aparc-a2009s lh area G-cingul-Post-ventral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0722101	0.1058948	0.5027522
Weighted median	23	0.0354598	0.0596888	0.5524596
Inverse variance weighted	23	0.0274568	0.0406329	0.4992133
Simple mode	23	0.0470020	0.1101200	0.6736546
Weighted mode	23	0.0703691	0.0892851	0.4390259

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.82969	21	0.3013833
Inverse variance weighted	24.06890	22	0.3436283

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027479	0.005985	0.6508587

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007445	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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