Two sample MR report

Telomere_length against aparc-a2009s lh area G-cingul-Post-dorsal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0935037	0.1182955	0.4381154
Weighted median	23	0.0316928	0.0545198	0.5610328
Inverse variance weighted	23	-0.0083515	0.0458167	0.8553627
Simple mode	23	0.0652857	0.0867999	0.4599388
Weighted mode	23	0.0241543	0.0623873	0.7023525

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.73799	21	0.0973810
Inverse variance weighted	30.60397	22	0.1045084

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052283	0.0066858	0.4429399

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009287	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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