Two sample MR report

Telomere_length against aparc-a2009s lh area G+S-transv-frontopol

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0538042	0.1195749	0.6573479
Weighted median	23	-0.0603551	0.0617781	0.3285862
Inverse variance weighted	23	-0.0596515	0.0456558	0.1913663
Simple mode	23	-0.1347685	0.1048493	0.2120353
Weighted mode	23	-0.0542171	0.0667555	0.4253928

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.38668	21	0.0844888
Inverse variance weighted	30.39076	22	0.1092720

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000359	0.0067581	0.958135

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009924	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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