Two sample MR report


Telomere_length against aparc-a2009s lh area G+S-subcentral

Date: 22 April, 2022


Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.1315752 0.1205776 0.2875437
Weighted median 23 -0.1183154 0.0571039 0.0382719
Inverse variance weighted 23 -0.0955022 0.0461512 0.0385147
Simple mode 23 -0.1217197 0.1004475 0.2384535
Weighted mode 23 -0.1182825 0.0605800 0.0637187

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 30.89855 21 0.0753630
Inverse variance weighted 31.05398 22 0.0950163

Test for directional horizontal pleiotropy

egger_intercept se pval
0.0022149 0.0068148 0.7483881

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0011241 TRUE 0

Note - R2 values are approximate


Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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