Two sample MR report

Telomere_length against aparc-a2009s lh area G+S-paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0220708	0.0994062	0.8264383
Weighted median	23	0.0005371	0.0608105	0.9929527
Inverse variance weighted	23	-0.0034080	0.0388453	0.9300888
Simple mode	23	0.0147585	0.1111945	0.8956160
Weighted mode	23	0.0262809	0.0748701	0.7289129

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.23916	21	0.6338235
Inverse variance weighted	18.31669	22	0.6870552

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015644	0.0056182	0.7833899

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005553	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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