Two sample MR report

Telomere_length against aparc-a2009s lh area G+S-occipital-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0610206	0.1275923	0.6374156
Weighted median	23	-0.0550412	0.0630943	0.3830101
Inverse variance weighted	23	0.0213152	0.0488458	0.6625634
Simple mode	23	-0.1175501	0.1125071	0.3074497
Weighted mode	23	-0.1058943	0.0809511	0.2043339

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.59845	21	0.0312347
Inverse variance weighted	34.78676	22	0.0407786

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024379	0.0072112	0.7386659

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010632	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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