Two sample MR report

Telomere_length against aparc-a2009s lh area G+S-frontomargin

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0796320	0.1209362	0.5173954
Weighted median	23	0.0323275	0.0652398	0.6202345
Inverse variance weighted	23	-0.0466980	0.0475669	0.3262315
Simple mode	23	0.0129415	0.1505061	0.9322551
Weighted mode	23	0.0503963	0.0926568	0.5919780

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.08275	21	0.0722918
Inverse variance weighted	32.98894	22	0.0620296

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0077567	0.0068351	0.269232

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010434	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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