Two sample MR report

Telomere_length against aparc-a2009s lh area G+S-cingul-Mid-Post

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0172995 0.1029560 0.8681691
Weighted median 23 -0.1073371 0.0576892 0.0627995
Inverse variance weighted 23 -0.0917965 0.0398820 0.0213520
Simple mode 23 0.0218867 0.1035605 0.8345654
Weighted mode 23 -0.1278601 0.0730723 0.0940946

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 22.52627 21 0.3697468
Inverse variance weighted 23.18911 22 0.3911178

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0045741 0.0058189 0.4405972

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0008719 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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