Two sample MR report

Telomere_length against aparc-a2009s lh area G+S-cingul-Mid-Ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0442832	0.1024673	0.6700240
Weighted median	23	-0.0916802	0.0578535	0.1130354
Inverse variance weighted	23	-0.0756486	0.0405992	0.0624196
Simple mode	23	0.0110168	0.0944342	0.9081870
Weighted mode	23	-0.0784600	0.0678010	0.2595976

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.31327	21	0.3816542
Inverse variance weighted	24.03121	22	0.3455956

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0073638	0.0057912	0.2174377

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008431	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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