Two sample MR report

Telomere_length against aparc-a2009s lh area G+S-cingul-Ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0869092	0.1135829	0.4526896
Weighted median	23	-0.1567673	0.0616048	0.0109363
Inverse variance weighted	23	-0.1205354	0.0472554	0.0107500
Simple mode	23	-0.1512547	0.1223529	0.2294144
Weighted mode	23	-0.1700694	0.0811779	0.0479004

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.41848	21	0.1574272
Inverse variance weighted	32.55854	22	0.0683596

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0127371	0.0064194	0.060463

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012783	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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