Two sample MR report

Telomere_length against aparc-a2009s lh area G-Ins-lg+S-cent-ins

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0074196	0.1245530	0.9530614
Weighted median	23	-0.0561777	0.0578818	0.3317674
Inverse variance weighted	23	-0.0213181	0.0476243	0.6544198
Simple mode	23	-0.0335571	0.0996778	0.7395666
Weighted mode	23	-0.0408527	0.0611573	0.5110856

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.96788	21	0.0465745
Inverse variance weighted	33.06652	22	0.0609443

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017645	0.0070395	0.8045151

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010111	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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