Two sample MR report

Telomere_length against aparc-Desikan rh volume transversetemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2194334	0.0994076	0.0385474
Weighted median	23	-0.0606101	0.0547420	0.2682098
Inverse variance weighted	23	-0.0100436	0.0388461	0.7959835
Simple mode	23	-0.0563278	0.0841612	0.5102777
Weighted mode	23	-0.0775386	0.0591336	0.2032968

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.82954	21	0.9144772
Inverse variance weighted	18.06600	22	0.7020682

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0128565	0.0056183	0.0325882

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005495	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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