Two sample MR report

Telomere_length against aparc-Desikan rh volume supramarginal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0315903	0.1369207	0.8197654
Weighted median	23	-0.0487659	0.0585797	0.4051426
Inverse variance weighted	23	-0.0672805	0.0523747	0.1989327
Simple mode	23	-0.1352658	0.1017981	0.1975438
Weighted mode	23	-0.0461233	0.0677125	0.5028756

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.84227	21	0.0077721
Inverse variance weighted	39.99442	22	0.0108280

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021914	0.0077384	0.779812

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013027	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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