Two sample MR report

Telomere_length against aparc-Desikan rh volume superiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0735264	0.1029768	0.4830831
Weighted median	23	-0.0873472	0.0573656	0.1278489
Inverse variance weighted	23	-0.0667261	0.0393205	0.0897008
Simple mode	23	-0.0894298	0.0951801	0.3576329
Weighted mode	23	-0.1003378	0.0658735	0.1419575

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.53621	21	0.3691956
Inverse variance weighted	22.54174	22	0.4279795

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004175	0.00582	0.9434867

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007725	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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