Two sample MR report

Telomere_length against aparc-Desikan rh volume superiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0368304	0.1012327	0.7196307
Weighted median	23	-0.0297589	0.0534465	0.5776654
Inverse variance weighted	23	-0.0231685	0.0388454	0.5508887
Simple mode	23	0.0120163	0.0861200	0.8903007
Weighted mode	23	-0.0210913	0.0673986	0.7572786

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.77870	21	0.4123574
Inverse variance weighted	21.80099	22	0.4718196

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008388	0.0057214	0.8848366

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006714	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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