Two sample MR report

Telomere_length against aparc-Desikan rh volume superiorfrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1356117	0.1219654	0.2787548
Weighted median	23	-0.1276946	0.0588429	0.0299997
Inverse variance weighted	23	-0.0435912	0.0473042	0.3567861
Simple mode	23	-0.0351891	0.0997947	0.7277332
Weighted mode	23	-0.1459572	0.0756824	0.0667897

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.61421	21	0.0640258
Inverse variance weighted	32.62562	22	0.0673380

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056501	0.0068933	0.4216193

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010267	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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