Two sample MR report

Telomere_length against aparc-Desikan rh volume rostralmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0125854	0.1210219	0.9181618
Weighted median	23	0.0110144	0.0591887	0.8523749
Inverse variance weighted	23	-0.0596191	0.0464009	0.1988378
Simple mode	23	0.0100945	0.1108504	0.9282657
Weighted mode	23	0.0267471	0.0884301	0.7651377

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.12712	21	0.0715682
Inverse variance weighted	31.39135	22	0.0883813

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028879	0.0068399	0.6771631

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010226	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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