Two sample MR report

Telomere_length against aparc-Desikan rh volume rostralanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0361513	0.0994074	0.7197413
Weighted median	23	-0.0612034	0.0543408	0.2600433
Inverse variance weighted	23	-0.0250553	0.0388458	0.5189321
Simple mode	23	-0.1634194	0.0948881	0.0990588
Weighted mode	23	-0.0694785	0.0598370	0.2580334

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.69513	21	0.7865284
Inverse variance weighted	15.70984	22	0.8300211

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006813	0.0056183	0.9046346

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004887	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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