Two sample MR report

Telomere_length against aparc-Desikan rh volume precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3224056	0.1089829	0.0075024
Weighted median	23	-0.0707836	0.0611731	0.2472299
Inverse variance weighted	23	-0.0307401	0.0492769	0.5327443
Simple mode	23	-0.0983121	0.1060834	0.3641154
Weighted mode	23	-0.1322023	0.0776896	0.1029086

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.24265	21	0.2368076
Inverse variance weighted	35.40364	22	0.0351418

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0179084	0.0061595	0.0084216

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010917	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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