Two sample MR report

Telomere_length against aparc-Desikan rh volume precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1677157	0.1279386	0.2040441
Weighted median	23	-0.0577390	0.0572018	0.3127869
Inverse variance weighted	23	-0.0476928	0.0500390	0.3405327
Simple mode	23	-0.0592243	0.0980632	0.5520609
Weighted mode	23	-0.0712201	0.0603773	0.2507648

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.78608	21	0.0297991
Inverse variance weighted	36.50667	22	0.0267771

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0073693	0.0072307	0.3197228

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011519	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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