Two sample MR report

Telomere_length against aparc-Desikan rh volume posteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1577160	0.1242574	0.2182326
Weighted median	23	0.0095987	0.0559883	0.8638770
Inverse variance weighted	23	-0.0177516	0.0500276	0.7227118
Simple mode	23	-0.0044011	0.0889231	0.9609727
Weighted mode	23	0.0244148	0.0626371	0.7004463

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.81220	21	0.0483414
Inverse variance weighted	36.48951	22	0.0268920

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0107736	0.0070227	0.1399313

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011119	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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