Two sample MR report

Telomere_length against aparc-Desikan rh volume postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2227542	0.1059208	0.0476963
Weighted median	23	-0.1244663	0.0543603	0.0220414
Inverse variance weighted	23	-0.0955444	0.0420467	0.0230660
Simple mode	23	-0.1798200	0.0871803	0.0511502
Weighted mode	23	-0.1427098	0.0609276	0.0286216

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.84345	21	0.3007057
Inverse variance weighted	25.77628	22	0.2614114

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0078107	0.0059864	0.2061013

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009644	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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