Two sample MR report

Telomere_length against aparc-Desikan rh volume pericalcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0466519	0.1093929	0.6741111
Weighted median	23	0.0382114	0.0626396	0.5418488
Inverse variance weighted	23	0.0227725	0.0422359	0.5897670
Simple mode	23	0.0470272	0.1122687	0.6793649
Weighted mode	23	0.0693784	0.1007567	0.4982889

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.4331	21	0.2288935
Inverse variance weighted	26.0088	22	0.2513043

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0042627	0.0061827	0.4980846

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007985	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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