Two sample MR report

Telomere_length against aparc-Desikan rh volume parstriangularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0074199	0.1421885	0.9588754
Weighted median	23	-0.0549907	0.0624922	0.3788804
Inverse variance weighted	23	-0.0259831	0.0543123	0.6323640
Simple mode	23	0.1985063	0.1480368	0.1936262
Weighted mode	23	-0.0622699	0.0720923	0.3970440

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.96754	21	0.0031735
Inverse variance weighted	43.00870	22	0.0047075

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0011398	0.0080361	0.8885653

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013167	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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