Two sample MR report

Telomere_length against aparc-Desikan rh volume parsorbitalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0599009	0.0994091	0.5532467
Weighted median	23	-0.0013384	0.0605721	0.9823715
Inverse variance weighted	23	-0.0152180	0.0388467	0.6952470
Simple mode	23	0.0122475	0.1045680	0.9078241
Weighted mode	23	0.0225659	0.0740707	0.7634938

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.92183	21	0.774027
Inverse variance weighted	16.59576	22	0.785260

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0046123	0.0056184	0.4209083

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005076	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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