Two sample MR report

Telomere_length against aparc-Desikan rh volume parsopercularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2021257	0.1141390	0.0910971
Weighted median	23	-0.0782063	0.0590011	0.1850036
Inverse variance weighted	23	-0.0647258	0.0453173	0.1532113
Simple mode	23	-0.0821136	0.0961551	0.4023250
Weighted mode	23	-0.1209630	0.0673799	0.0863671

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.68764	21	0.1492347
Inverse variance weighted	29.94259	22	0.1198665

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0084364	0.0064509	0.2050834

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009914	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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