Two sample MR report

Telomere_length against aparc-Desikan rh volume parahippocampal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0540889	0.1044484	0.6099738
Weighted median	23	0.0000047	0.0534201	0.9999293
Inverse variance weighted	23	0.0279115	0.0405620	0.4913784
Simple mode	23	-0.0141981	0.0871391	0.8720566
Weighted mode	23	-0.0173177	0.0590740	0.7721529

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.18418	21	0.3342376
Inverse variance weighted	23.98727	22	0.3478971

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050348	0.0059031	0.4033399

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007425	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8