Two sample MR report

Telomere_length against aparc-Desikan rh volume paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1194120	0.1211874	0.3356695
Weighted median	23	-0.0754141	0.0590248	0.2013661
Inverse variance weighted	23	-0.0059817	0.0473937	0.8995636
Simple mode	23	0.0539404	0.1212083	0.6606517
Weighted mode	23	-0.0804416	0.0762742	0.3030365

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.21192	21	0.0702027
Inverse variance weighted	32.74870	22	0.0654974

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069646	0.0068492	0.3208

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000993	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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