Two sample MR report

Telomere_length against aparc-Desikan rh volume middletemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1581587	0.0994038	0.1265353
Weighted median	23	0.0596700	0.0587311	0.3096358
Inverse variance weighted	23	0.0224509	0.0388448	0.5632884
Simple mode	23	0.0659521	0.1051154	0.5368383
Weighted mode	23	0.0723986	0.1000213	0.4767959

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.55279	21	0.8447049
Inverse variance weighted	18.44901	22	0.6790597

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0110895	0.0056181	0.0616957

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005692	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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