Two sample MR report

Telomere_length against aparc-Desikan rh volume medialorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0193736	0.1595050	0.9044810
Weighted median	23	-0.0966680	0.0684750	0.1580299
Inverse variance weighted	23	-0.0577365	0.0609973	0.3438720
Simple mode	23	-0.1709158	0.1460772	0.2545056
Weighted mode	23	-0.1709158	0.1322948	0.2097884

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	54.07474	21	0.0000963
Inverse variance weighted	54.25054	22	0.0001516

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023555	0.009015	0.796415

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017106	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

Funnel plot

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Leave-one-out sensitivity analysis

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