Two sample MR report

Telomere_length against aparc-Desikan rh volume lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1809973	0.1112833	0.1187661
Weighted median	23	0.0516999	0.0627070	0.4096741
Inverse variance weighted	23	0.0137742	0.0459994	0.7646022
Simple mode	23	0.1464307	0.1244363	0.2518698
Weighted mode	23	0.0898746	0.0813600	0.2812457

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.31887	21	0.1945505
Inverse variance weighted	30.84999	22	0.0992262

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.011959	0.0062895	0.0710564

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009386	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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