Two sample MR report

Telomere_length against aparc-Desikan rh volume lateralorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0862631	0.1164419	0.4670028
Weighted median	23	-0.0455920	0.0614476	0.4581078
Inverse variance weighted	23	0.0152629	0.0449185	0.7340133
Simple mode	23	-0.0719729	0.1189830	0.5514338
Weighted mode	23	-0.0752685	0.0806885	0.3610341

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.81539	21	0.1185047
Inverse variance weighted	29.41749	22	0.1333229

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043594	0.0065811	0.5149074

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008961	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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