Two sample MR report

Telomere_length against aparc-Desikan rh volume lateraloccipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0855743	0.1198058	0.4829213
Weighted median	23	-0.0283954	0.0584499	0.6271039
Inverse variance weighted	23	-0.0036778	0.0463370	0.9367374
Simple mode	23	-0.0346040	0.0917284	0.7096073
Weighted mode	23	-0.0305400	0.0677102	0.6563751

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.50338	21	0.0823296
Inverse variance weighted	31.30444	22	0.0900521

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050284	0.0067711	0.465935

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009488	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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