Two sample MR report

Telomere_length against aparc-Desikan rh volume insula

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1680916	0.1196049	0.1745275
Weighted median	23	-0.0287938	0.0589619	0.6253042
Inverse variance weighted	23	-0.0099333	0.0478550	0.8355647
Simple mode	23	0.1266613	0.1082114	0.2543238
Weighted mode	23	-0.0427042	0.0625721	0.5020591

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.40154	21	0.0842112
Inverse variance weighted	33.38917	22	0.0566053

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0097108	0.0067597	0.1655734

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010137	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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