Two sample MR report

Telomere_length against aparc-Desikan rh volume inferiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0441279	0.1284595	0.7346258
Weighted median	23	0.0548881	0.0631166	0.3845026
Inverse variance weighted	23	-0.0407669	0.0490466	0.4058671
Simple mode	23	0.0342655	0.1298735	0.7943609
Weighted mode	23	0.0759189	0.0943531	0.4296456

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.07285	21	0.0277197
Inverse variance weighted	35.07420	22	0.0380590

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002064	0.0072604	0.9775928

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010961	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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