Two sample MR report

Telomere_length against aparc-Desikan rh volume inferiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0077958	0.1165043	0.9472828
Weighted median	23	-0.0631190	0.0564796	0.2637582
Inverse variance weighted	23	-0.0509225	0.0446511	0.2540975
Simple mode	23	0.0705492	0.1030018	0.5005402
Weighted mode	23	-0.0549438	0.0648286	0.4058292

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.84559	21	0.1177582
Inverse variance weighted	29.06773	22	0.1429371

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0026479	0.0065845	0.6916386

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009328	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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